The Medical Letter on Drugs and Therapeutics
Elvitegravir (Vitekta) for HIV
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The FDA has approved elvitegravir (Vitekta – Gilead), an integrase strand transfer inhibitor (INSTI), for use with a protease inhibitor (PI) plus ritonavir and other antiretroviral drugs for treatment of HIV-1 infection in treatment-experienced adults. Elvitegravir is also available in a fixed-dose combination (Stribild) with the pharmacokinetic enhancer cobicistat and the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) emtricitabine and tenofovir disoproxil fumarate (DF).1 A similar combination (Genvoya) that includes tenofovir alafenamide instead of tenofovir DF was recently approved by the FDA and will be reviewed in a future issue.

TREATMENT OF HIV — First-line therapy for HIV usually consists of two NRTIs in combination with either darunavir boosted with ritonavir or an INSTI. The choice of drugs for treatment-experienced ... more      

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Title: Elvitegravir (Vitekta) for HIV
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