The Medical Letter on Drugs and Therapeutics
Isavuconazonium Sulfate (Cresemba) - A New Antifungal
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The FDA has approved isavuconazonium sulfate (Cresemba – Astellas) for intravenous and oral treatment of invasive aspergillosis and invasive mucormycosis in adults. Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum triazole antifungal.

STANDARD TREATMENT — Voriconazole (Vfend, and generics) is the preferred treatment for invasive aspergillosis. Some experts recommend addition of an echinocandin (see Table 2), but the role of combination therapy for initial treatment has not been well established.1 A lipid formulation of amphotericin B (AmBisome, Abelcet) is generally used in patients who cannot tolerate voriconazole. Patients who do not respond to monotherapy are usually treated with an echinocandin in addition to voriconazole or a lipid formulation of amphotericin B. ... more      

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Title: Isavuconazonium Sulfate (Cresemba) - A New Antifungal
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