The Medical Letter on Drugs and Therapeutics
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SGLT2 Inhibitors and Renal Function

At the same time that the FDA announced it was strengthening existing warnings about the risk of acute kidney injury in patients with type 2 diabetes treated with the sodium-glucose co-transporter 2 (SGLT2) inhibitors canagliflozin (Invokana, and others) and dapagliflozin (Farxiga, and others),1 a study was published showing that the third SGLT2 inhibitor, empagliflozin (Jardiance, and others), slowed the progression of renal dysfunction in patients with type 2 diabetes.2

SGLT2 INHIBITION — SGLT2, a membrane protein expressed mainly in the kidney, transports filtered glucose from the proximal renal tubule into tubular epithelial cells. SGLT2 inhibitors decrease renal glucose and sodium reabsorption and increase urinary glucose excretion, resulting in lower blood glucose levels and a modest reduction in HbA1c. ... more      

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