The Medical Letter on Drugs and Therapeutics
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August 1, 2016
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Jentadueto XR for Type 2 Diabetes
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August 1, 2016 (Issue: 1500)

The FDA has approved Jentadueto XR (Boehringer Ingelheim/Lilly), a once-daily extended-release formulation of the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin and the biguanide metformin, for oral treatment of type 2 diabetes. Linagliptin and metformin have been available for years in a twice-daily immediate-release combination (Jentadueto).1 Once-daily extended-release formulations combining metformin with the DPP-4 inhibitors saxagliptin (Kombiglyze XR) and sitagliptin (Janumet XR) are also available.2

CLINICAL STUDIES — No new trials were required for approval of Jentadueto XR, which was based on earlier trials of linagliptin coadministered with metformin. Taking immediate-release linagliptin and metformin together has been shown to reduce A1C by an additional 0.5-1.1% compared to taking ... more      

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