The Medical Letter on Drugs and Therapeutics
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1510
Drugs for Psychotic Disorders
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Oral antipsychotic drugs used for treatment of schizophrenia, schizoaffective disorder, delusional disorder, and other manifestations of psychosis or mania are listed in Table 1. Parenteral antipsychotic drugs used for treatment of these disorders are listed in Table 2.

EFFECTIVENESS — Antipsychotic drugs are more effective in treating the positive symptoms of schizophrenia (agitation, hallucinations, delusions) than the negative symptoms (apathy, social withdrawal, blunted affect).1,2

Oral – Second-generation antipsychotics are used more commonly than less expensive first-generation drugs, even though controlled trials generally have failed to demonstrate a clear advantage in efficacy, except with clozapine and possibly olanzapine.3

Clozapine ... more      

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