The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1563
ISSUE 1563
January 14, 2019
Dupilumab (Dupixent) for Asthma
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January 14, 2019 (Issue: 1563)
The FDA has approved the subcutaneously injected
monoclonal antibody dupilumab (Dupixent – Sanofi/Regeneron) for add-on maintenance treatment of
patients ≥12 years old with moderate to severe
asthma with an eosinophilic phenotype or with oral
corticosteroid-dependent asthma. Dupilumab was
approved earlier to treat adults with moderate to
severe atopic dermatitis inadequately controlled with
topical therapies.
... more
- Dupilumab (Dupixent) for moderate to severe atopic dermatitis. Med Lett Drugs Ther 2017; 59:64.
- S Wenzel et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013; 368:2455.
- Benralizumab (Fasenra) for severe eosinophilic asthma. Med Lett Drugs Ther 2018; 60:33.
- Mepolizumab (Nucala) for severe eosinophilic asthma. Med Lett Drugs Ther 2016; 58:11.
- Reslizumab (Cinqair) for severe eosinophilic asthma. Med Lett Drugs Ther 2016; 58:81.
- Drugs for asthma. Med Lett Drugs Ther 2017; 59:139.
- S Wenzel et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 2016; 388:31.
- M Castro et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med 2018; 378:2486.
- KF Rabe et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. N Engl J Med 2018; 378:2475.

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Title: Dupilumab (Dupixent) for Asthma
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