The Medical Letter on Drugs and Therapeutics
Desmopressin (Nocdurna and Noctiva) for Nocturnal Polyuria
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The FDA has approved a sublingual tablet (Nocdurna – Ferring) and a nasal spray (Noctiva – Avadel) formulation of desmopressin acetate for treatment of nocturia due to nocturnal polyuria in adults who wake up ≥2 times per night to void. Nocdurna and Noctiva are the first two products to be approved in the US for this indication. Higher-strength nasal spray and oral tablet formulations of desmopressin (DDAVP, and others) have been available for years for treatment of diabetes insipidus and primary nocturnal enuresis (bedwetting in children). In 2007, the indication for primary nocturnal enuresis was removed from the labels of the nasal spray formulations because their use resulted in 61 cases of hyponatremia-related seizures, 2 of which resulted in death. ... more
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Title: Desmopressin (Nocdurna and Noctiva) for Nocturnal Polyuria
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