The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1615
ISSUE 1615
January 11, 2021
Opicapone (Ongentys) - A COMT Inhibitor for Parkinson's Disease
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January 11, 2021 (Issue: 1615)
The FDA has approved opicapone (Ongentys –
Neurocrine), a peripherally-acting reversible catechol-O-methyltransferase (COMT) inhibitor, for oral use as an
adjunct to carbidopa/levodopa in adults with Parkinson’s
disease (PD) who experience "off" episodes. It is the
third COMT inhibitor to be approved for this indication;
tolcapone (Tasmar, and generics) and entacapone
(Comtan, and generics) were approved earlier. Opicapone
has been available in Europe since 2016.
... more
- Drugs for Parkinson's disease. Med Lett Drugs Ther 2017; 59:187.
- SH Fox et al. International Parkinson and Movement Disorder Society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson's disease. Mov Disord 2018; 33:1248.
- Istradefylline (Nourianz) for Parkinson's disease. Med Lett Drugs Ther 2020; 62:20.
- Sublingual apomorphine (Kynmobi) for Parkinson's disease. Med Lett Drugs Ther 2020; 62:165.
- Inhaled levodopa (Inbrija) for Parkinson's disease. Med Lett Drugs Ther 2019; 61:73.
- JJ Ferreira et al. Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. Lancet Neurol 2016; 15:154.
- AJ Lees et al. Opicapone as adjunct to levodopa therapy in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol 2017; 74:197.
- JJ Ferreira et al. Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open-label extensions. Eur J Neurol 2019; 26:953.

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