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Clopidogrel (Plavix) Revisited
The Medical Letter on Drugs and Therapeutics • Apr 10, 2006 (Issue 1232)
>80% with stent (2,658) or ticlopidine + ASA revascularization 6.4% placebo/ASA (p=0.03)
x 2-4 wks ...
Clopidogrel (Plavix - Sanofi-Aventis and Bristol-Myers Squibb), an oral thienopyridine that inhibits platelet aggregation, is now being advertised directly to the public on television. Clopidogrel is approved by the FDA for secondary prevention of myocardial infarction (MI), stroke and other vascular events and for use in patients with acute coronary syndrome (unstable angina or non-ST-elevation MI), including those undergoing angioplasty. It is used off-label for patients with ST-elevation acute MI