Search Results for "Chemotherapy"
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Searched for Chemotherapy. Results 41 to 50 of 220 total matches.

Quizartinib (Vanflyta) for Acute Myeloid Leukemia (online only)

   
The Medical Letter on Drugs and Therapeutics • Oct 16, 2023  (Issue 1687)
, and as maintenance monotherapy following consolidation chemotherapy in adults with FLT3 internal tandem duplication ...
The FDA has approved the oral kinase inhibitor quizartinib (Vanflyta – Daiichi Sankyo) for use in combination with standard cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy in adults with FLT3 internal tandem duplication (ITD)-positive, newly-diagnosed acute myeloid leukemia (AML).
Med Lett Drugs Ther. 2023 Oct 16;65(1687):e169-70   doi:10.58347/tml.2023.1687d |  Show IntroductionHide Introduction

Drugs for Breast Cancer

   
Treatment Guidelines from The Medical Letter • Jan 01, 2005  (Issue 29)
and their adverse effects begins on page 3. ADJUVANT THERAPY CHEMOTHERAPY — Adjuvant combination chemotherapy ...
In addition to surgery and radiation therapy, a variety of drugs are used both singly and in combination to treat breast cancer. This article summarizes the principles of adjuvant therapy and treatment for metastatic disease. A summary of individual drugs and their adverse effects begins on page 3.
Treat Guidel Med Lett. 2005 Jan;3(29):1-6 |  Show IntroductionHide Introduction

Tebentafusp (Kimmtrak) for Uveal Melanoma (online only)

   
The Medical Letter on Drugs and Therapeutics • Jun 24, 2024  (Issue 1705)
. Patients were randomized to receive tebentafusp or investigator-selected chemotherapy (pembrolizumab ...
The FDA has approved tebentafusp-tebn (Kimmtrak – Immunocore), a first-in-class bispecific gp100 peptide-HLA-directed CD3 T-cell engager, for treatment of HLA-A*02:01-positive unresectable or metastatic uveal melanoma in adults.
Med Lett Drugs Ther. 2024 Jun 24;66(1705):e107-8   doi:10.58347/tml.2024.1705f |  Show IntroductionHide Introduction

Plerixafor (Mozobil)

   
The Medical Letter on Drugs and Therapeutics • Apr 05, 2010  (Issue 1335)
chemotherapy with autologous stem cell rescue. STANDARD TREATMENT — High-dose chemotherapy can overcome ...
The FDA has approved plerixafor (Mozobil – Genzyme), a CXCR4 chemokine receptor antagonist, for use in combination with granulocyte-colony stimulating factor (G-CSF; Neupogen) to mobilize peripheral blood stem cells in adults with multiple myeloma or non-Hodgkin’s lymphoma before high-dose chemotherapy with autologous stem cell rescue.
Med Lett Drugs Ther. 2010 Apr 5;52(1335):27-8 |  Show IntroductionHide Introduction

Sacituzumab Govitecan (Trodelvy) for Metastatic Triple-Negative Breast Cancer (online only)

   
The Medical Letter on Drugs and Therapeutics • Feb 08, 2021  (Issue 1617)
conjugate to become available in the US. Standard Treatment – Sequential single-agent chemotherapy ...
The FDA has approved sacituzumab govitecan-hziy (Trodelvy – Immunomedics), a trophoblast cell-surface antigen-2 (Trop-2)-directed antibody and topoisomerase inhibitor conjugate, for treatment of adults with metastatic triple-negative breast cancer who have received ≥2 prior therapies for metastatic disease. It is the first Trop-2-directed antibody-drug conjugate to become available in the US.
Med Lett Drugs Ther. 2021 Feb 8;63(1617):e24-5 |  Show IntroductionHide Introduction

Erythropoietin Safety Concerns

   
The Medical Letter on Drugs and Therapeutics • May 07, 2007  (Issue 1260)
chemotherapy have found an increased risk of thromboembolic events, disease progression and mortality ...
The erythropoiesis-stimulating agents (ESAs) epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp) are widely used for treatment of anemia and to reduce the need for red blood cell transfusions. Based on the results of recent clinical trials indicating an increased risk of serious adverse events and death associated with ESAs, particularly when used to achieve a hemoglobin concentration ≥12 g/dL, the FDA has revised the prescribing information for these drugs to include a black box warning.
Med Lett Drugs Ther. 2007 May 7;49(1260):37-9 |  Show IntroductionHide Introduction

In Brief: A New Prostate Cancer Indication for Olaparib (Lynparza) (online only)

   
The Medical Letter on Drugs and Therapeutics • Jun 26, 2023  (Issue 1679)
)-negative, high-risk early breast cancer who received prior neoadjuvant or adjuvant chemotherapy.1 It had ...
The oral poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Lynparza – AstraZeneca) has now been approved by the FDA for use in combination with abiraterone (Zytiga, and others) and either prednisone or prednisolone for treatment of adults with deleterious or suspected deleterious BRCA-mutated (BRCAm) metastatic castration-resistant prostate cancer (mCRPC). Olaparib was previously approved by the FDA for treatment of adults with deleterious or suspected deleterious germline or somatic homologous recombinant repair (HRR) genemutated mCRPC who progressed on prior treatment with...
Med Lett Drugs Ther. 2023 Jun 26;65(1679):e106-7   doi:10.58347/tml.2023.1679g |  Show IntroductionHide Introduction

Amivantamab (Rybrevant) for Non-Small Cell Lung Cancer (online only)

   
The Medical Letter on Drugs and Therapeutics • Nov 14, 2022  (Issue 1663)
chemotherapy. It is the first bispecific antibody to become available in the US for this indication ...
Amivantamab-vmjw (Rybrevant – Janssen), an EGFR-MET bispecific antibody, has received accelerated approval from the FDA for IV treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations in adults whose disease has progressed on or after platinum-based chemotherapy. It is the first bispecific antibody to become available in the US for this indication. Accelerated approval of the drug was based on the overall response rate and duration of response.
Med Lett Drugs Ther. 2022 Nov 14;64(1663):e184-5 |  Show IntroductionHide Introduction

Erlotinib (Tarceva) for Advanced Non-Small Cell Lung Cancer

   
The Medical Letter on Drugs and Therapeutics • Mar 28, 2005  (Issue 1205)
for patients who have failed at least one prior chemotherapy regimen. Cetuximab (Erbitux), the only ...
Erlotinib (Tarceva) is the second oral epidermal growth factor receptor (EGFR) inhibitor to become available in the US for treatment of advanced refractory NSCLC. In clinical trials, erlotinib produced a response rate of only 8.9%, but increased median survival from 4.7 to 6.7 months. Patients who had never smoked and those with EGFR-positive tumors survived longer. Erlotinib is generally well tolerated; diarrhea and rash are the most common adverse effects.
Med Lett Drugs Ther. 2005 Mar 28;47(1205):25-6 |  Show IntroductionHide Introduction

Zarxio - A Filgrastim Biosimilar

   
The Medical Letter on Drugs and Therapeutics • Mar 14, 2016  (Issue 1490)
chemotherapy treatment of patients with acute myeloid leukemia ▶ Reduce the duration of neutropenia ...
The FDA has approved filgrastim-sndz (Zarxio – Sandoz), a biosimilar of the recombinant human granulocyte colony-stimulating factor filgrastim (G-CSF; Neupogen), which has been available in the US since 1991. Zarxio is the first biosimilar product to be approved in the US; it has been available in Europe as Zarzio since 2009.
Med Lett Drugs Ther. 2016 Mar 14;58(1490):34-5 |  Show IntroductionHide Introduction