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See also: ondansetron

Figure 1: Treatments for Irritable Bowel Syndrome (IBS) in Adults (online only)

   
The Medical Letter on Drugs and Therapeutics • Feb 03, 2025  (Issue 1721)
Pain IBS-C IBS-D Zofran eluxadoline Viberzi alosetron Lotronex probiotics ondansetron Xifaxan ...
View Figure: Treatments for Irritable Bowel Syndrome (IBS) in Adults
Med Lett Drugs Ther. 2025 Feb 3;67(1721):e1   doi:10.58347/tml.2025.1721c |  Show IntroductionHide Introduction

Comparison Chart: Safety of Drugs for IBS in Pregnancy and Lactation (online only)

   
The Medical Letter on Drugs and Therapeutics • Feb 03, 2025  (Issue 1721)
in breast milk Ondansetron (Zofran) ▶ Majority of data suggest no increased risk of congenital ...
View the Comparison Chart: Safety of Drugs for IBS in Pregnancy and Lactation
Med Lett Drugs Ther. 2025 Feb 3;67(1721):e1-2   doi:10.58347/tml.2025.1721b |  Show IntroductionHide Introduction

Onapgo — An Apomorphine Subcutaneous Infusion for Parkinson's Disease

   
The Medical Letter on Drugs and Therapeutics • Jul 21, 2025  (Issue 1733)
antagonists such as ondansetron (Zofran, and others) can cause severe hypotension and loss of consciousness ...
Onapgo (Supernus), a solution for continuous subcutaneous infusion containing the dopamine agonist apomorphine, has been approved by the FDA for treatment of motor fluctuations in adults with advanced Parkinson's disease (PD). Subcutaneously injected apomorphine (Apokyn, and generics) has been available for intermittent use for years. Vyalev, a foscarbidopa/foslevodopa solution for subcutaneous infusion, was approved in 2024 for the same indication.
Med Lett Drugs Ther. 2025 Jul 21;67(1733):116-8   doi:10.58347/tml.2025.1733d |  Show IntroductionHide Introduction

Drugs for Irritable Bowel Syndrome

   
The Medical Letter on Drugs and Therapeutics • Feb 03, 2025  (Issue 1721)
(Zofran, and generics), a 5-HT3 receptor antagonist, is FDA-approved for prevention of chemotherapy ...
Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain and altered bowel habits, often accompanied by bloating. IBS is classified by its predominant bowel symptom: constipation (IBS-C), diarrhea (IBS-D), mixed type (IBS-M), or unclassified (IBS-U). Since the exact cause of IBS is unknown, the goal of treatment is symptom control. Some over-the-counter (OTC) products and prescription drugs for IBS are listed in Tables 1-4. The safety of these drugs during pregnancy and lactation is described in Table 5 (online only).
Med Lett Drugs Ther. 2025 Feb 3;67(1721):17-24   doi:10.58347/tml.2025.1721a |  Show IntroductionHide Introduction