Search Results for "mitotane"
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See also: Lysodren
Osilodrostat (Isturisa) for Cushing's Disease
The Medical Letter on Drugs and Therapeutics • Feb 08, 2021 (Issue 1617)
synthesis and
can be used in pregnant women. Mitotane (Lysodren),
an adrenal cytotoxic agent and inhibitor ...
The FDA has approved osilodrostat (Isturisa –
Recordati), a cortisol synthesis inhibitor, for oral
treatment of adults with Cushing's disease when
surgical resection of the pituitary adenoma is not an
option or has not been curative. Osilodrostat is the
first cortisol synthesis inhibitor to be approved in
the US for this indication. Other oral steroidogenesis
inhibitors such as ketoconazole and metyrapone have
been used off-label for this indication for many years.
Table: Inhibitors and Inducers of CYP Enzymes, P-Glycoprotein, and Other Transporters (online only)
The Medical Letter on Drugs and Therapeutics • Feb 06, 2023 (Issue 1669)
dexamethasone
efavirenz
elagolix
enzalutamide*
etravirine
mavacamten
mitotane*
mobocertinib
modafinil ...
View the Inhibitors and Inducers of CYP Enzymes, P-Glycoprotein, and Other Transporters tables
Med Lett Drugs Ther. 2023 Feb 6;65(1669):e28-30 doi:10.58347/tml.2023.1669g | Show Introduction Hide Introduction