The Medical Letter on Drugs and Therapeutics
Drugs for Epilepsy
July 31, 2017 (Issue: 1526)Treatment of epilepsy should begin with a single antiepileptic drug (AED), increasing its dosage gradually until seizures are controlled or adverse effects become intolerable. If seizures persist, specialists generally recommend trying at...more
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- Clobazam (Onfi) for Lennox-Gastaut syndrome. Med Lett Drugs Ther 2012; 54:18.
- Eslicarbazepine acetate (Aptiom) for epilepsy. Med Lett Drugs Ther 2014; 56:42.
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- Once-daily gabapentin (Gralise) for postherpetic neuralgia. Med Lett Drugs Ther 2011; 53:94.
- Gabapentin enacarbil (Horizant) for restless legs syndrome. Med Lett Drugs Ther 2011; 53:70.
- Lacosamide for epilepsy. Med Lett Drugs Ther 2009; 51:50.
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- Spritam – a new formulation of levetiracetam for epilepsy. Med Lett Drugs Ther 2016; 58:78.
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- Rufinamide (Banzel) for epilepsy. Med Lett Drugs Ther 2009; 51:18.
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- Topiramate extended-release (Trokendi XR) for epilepsy. Med Lett Drugs Ther 2013; 55:87.
- Topiramate (Topamax) for prevention of migraine. Med Lett Drugs Ther 2005; 47:9.
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- Vigabatrin (Sabril) for epilepsy. Med Lett Drugs Ther 2010; 52:14.
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- DS Reddy. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol 2010; 3:183.
- DS Reddy. Do oral contraceptives increase epileptic seizures? Expert Rev of Neurother 2017; 17:129.
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- KJ Meador et al. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years. Neurology 2012; 78:1207.
- J Christensen et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013; 309:1696.
- S Hernández-Diaz et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012; 78:1692.
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- MD Privitera et al. Generic-to-generic lamotrigine switches in people with epilepsy: the randomised controlled EQUIGEN trial. Lancet Neurol 2016; 15:365.
- AS Kesselheim et al. Switching generic antiepileptic drug manufacturer not linked to seizures. Neurology 2016; 87:1796.
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