Treatment Guidelines from The Medical Letter
Drugs for Migraine
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Drugs for treatment of migraine are listed in Table 2 on page 9. Drugs for prevention of migraine are listed in Table 3 on page 10. Treatment of migraine in the emergency room, which may involve use of intravenous drugs, is not included here.


Treatment with a nonopioid analgesic may be sufficient for mild or moderate episodes of migraine without nausea, disability or a need for bed rest. Aspirin and acetaminophen1 alone have been shown to be effective for treatment of migraine. A combination of acetaminophen, aspirin and caffeine (Excedrin Migraine, and others) is available over the counter (OTC). Midrin, which contains acetaminophen, isometheptene (a sympathomimetic amine) and dichloralphenazone (a chloral hydrate compound), has also been used for mild to moderate migraine. Aspirin ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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