The Medical Letter on Drugs and Therapeutics
Who Should Take Vitamin Supplements?
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Revised 1/25/12: The first paragraph on vitamin E has been revised.

Many patients ask their healthcare providers whether they should take vitamins. Since the last Medical Letter article on this subject,1 more data have become available on the benefits and risks of taking vitamins.

VITAMIN E — Vitamin E in food or supplements acts as an antioxidant, but under some conditions may have a pro-oxidant effect.2 High doses of vitamin E may interfere with vitamin K metabolism and platelet function.

Effect on Mortality – A meta-analysis of 26 clinical trials including 105,065 subjects found that supplementation with vitamin E alone or in combination with beta-carotene and vitamin A was associated with an increased risk of death.3

Pregnancy – A meta-analysis of 9 trials involving 19,810 pregnant women found that vitamin E and ... more      

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Title: Who Should Take Vitamin Supplements?
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