The Medical Letter on Drugs and Therapeutics
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Drugs for Migraine
Revised 2/1/18: In Table 2, Sumavel DosePro has been discontinued.

An oral nonopioid analgesic may be sufficient for treatment of mild to moderate migraine without severe nausea or vomiting. A triptan is the drug of choice for treatment of moderate to severe migraine.1,2 Use of a triptan early in an attack when pain is still mild to moderate in intensity improves headache response and reduces recurrence rates.

ANALGESICS – Aspirin and acetaminophen, used alone or together in combination with caffeine (Excedrin Migraine, and others), and nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen sodium (Aleve, and others) and ibuprofen (Advil, Motrin, and generics) are effective in relieving mild to moderate migraine pain.3-5 The NSAID diclofenac is FDA-approved as a powder for oral ... more      

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