Search Results for "Drug Interactions"
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Searched for Drug Interactions. Results 11 to 20 of 1090 total matches.
Drug Interaction: Opioids and Oral P2Y12 Platelet Inhibitors
The Medical Letter on Drugs and Therapeutics • Feb 25, 2019 (Issue 1566)
Drug Interaction: Opioids and Oral P2Y12 Platelet Inhibitors ...
The FDA has required manufacturers of the oral P2Y12
platelet inhibitors clopidogrel (Plavix, and generics),
prasugrel (Effient, and generics), and ticagrelor
(Brilinta) to warn in the product labels that the
absorption of these drugs may be delayed or reduced
when taken with an opioid agonist.
Addendum: Drug Interaction between Opioids and Oral P2Y12 Platelet Inhibitors
The Medical Letter on Drugs and Therapeutics • Mar 09, 2020 (Issue 1593)
Addendum: Drug Interaction between Opioids and Oral P2Y12 Platelet Inhibitors ...
Opioids delay gastric emptying and the absorption of many
oral drugs, including the P2Y12 inhibitors clopidogrel (Plavix,
and generics), prasugrel (Effient, and generics), and ticagrelor
(Brilinta), which are commonly used for initial treatment of
acute coronary syndrome (ACS). An article in our February 25,
2019 issue reviewed studies showing that coadministration
of opioids delayed and decreased absorption of oral P2Y12
inhibitors and increased platelet reactivity. Recently published
clinical outcomes data may add to these concerns.
Grapefruit Juice Interactions With Drugs
The Medical Letter on Drugs and Therapeutics • Aug 18, 1995 (Issue 955)
Grapefruit Juice Interactions With Drugs ...
In a study of the interaction between alcohol and the calcium-channel blocker felodipine (Plendil), the grapefruit juice vehicle for the alcohol appeared to increase felodipine plasma concentrations. Subsequent studies have found that grapefruit juice increases plasma concentrations of several calcium-channel blockers and of some other drugs as well (DG Bailey et al, Clin Pharmacokinet, 26:91, 1994).
PPI Interactions with Clopidogrel
The Medical Letter on Drugs and Therapeutics • Jan 12, 2009 (Issue 1303)
assessment of clinical impact of a drug
interaction between clopidogrel and proton pump inhibitors. J
Am ...
Clopidogrel (Plavix), which prevents arterial thrombosis by inhibiting platelet activation, is commonly prescribed (usually with aspirin) for months after acute coronary syndromes and stent implantation. It may also, however, increase the risk of bleeding. Therefore, a proton pump inhibitor (PPI) such as omeprazole (Prilosec, and others) is often given concurrently to decrease the risk of gastrointestinal (GI) bleeding. Some reports have suggested that omeprazole may interfere with the antiplatelet effect of clopidogrel.
Addendum: Warfarin-Acetaminophen Interaction
The Medical Letter on Drugs and Therapeutics • Jun 16, 2008 (Issue 1288)
Cholestyramine drug interactions 2008 5FU addendum Adrucil amiodarone anticoagulants Bactrim Barbiturates ...
A reader expressed disappointment that our recent listing of “Some Warfarin Drug Interactions”1 did not include acetaminophen. Perhaps it should have. Acetaminophen can increase the anticoagulant effect of warfarin, particularly with continued use, but it does so inconsistently. The mechanism of this interaction has not been established, but may be related to an acetaminophen metabolite inhibiting vitamin K-epoxide reductase, the target for warfarin’s anticoagulant effect.2Patient susceptibility varies, possibly on a genetic basis; occasional use of acetaminophen generally has little or...
PPI Interactions with Clopidogrel Revisted
The Medical Letter on Drugs and Therapeutics • Feb 23, 2009 (Issue 1306)
. PPI interactions with clopidogrel. Med Lett Drugs Ther 2009; 51:2.
3. JL Mega et al. Cytochrome P-450 ...
Current guidelines recommend use of a proton pump inhibitor (PPI) to decrease the risk of gastrointestinal bleeding in patients taking clopidogrel (Plavix) with aspirin. A recent issue of The Medical Letter considered whether omeprazole (Prilosec, and others) or other PPIs could interfere with the antiplatelet effect of clopidogrel. The conclusion was that patients taking both drugs should probably continue to do so until more data became available. Several new publications require reconsideration of that recommendation.
In Brief: Tamoxifen and SSRI Interactions
The Medical Letter on Drugs and Therapeutics • Jun 15, 2009 (Issue 1314)
Zoloft Wellbutrin Volume 51 Terbinafine Tamoxifen SSRIs SSRI Drug Interactions sertraline Selective ...
Use of a selective serotonin reuptake inhibitor (SSRI) is common in women taking tamoxifen (Nolvadex, and others) for breast cancer, both to treat depression and to decrease hot flashes. However, tamoxifen must be metabolized by CYP2D6 to become pharmacologically fully active (MJ Higgins et al. J Natl Compr Canc Netw 2009; 7:203), and the SSRIs fluoxetine (Prozac, and others) and paroxetine (Paxil, and others) are strong inhibitors of CYP2D6. Sertraline (Zoloft, and others) inhibits CYP2D6 to a lesser extent. Citalopram (Celexa, and others) and escitalopram (Lexapro), the 2 other SSRIs...
Foods Interacting With MAO Inhibitors
The Medical Letter on Drugs and Therapeutics • Feb 10, 1989 (Issue 785)
pargyline (Eutonyl). They can also interact with other drugs, such as sympathomimetic amines found ...
Many fermented foods contain tyramine as a byproduct formed by the bacterial breakdown of the amino acid tyrosine; it can also be formed by para-hydroxylation of phenylethylamine or dehydroxylation of DOPA and dopamine. Tyramine and some other amines found in food can cause hypertensive reactions in patients taking monoamine oxidase (MAO)inhibitors.
Drugs for Epilepsy
The Medical Letter on Drugs and Therapeutics • Jul 31, 2017 (Issue 1526)
such as ease of
use, adverse effects, drug interactions, presence of
comorbidities, and cost.
Newer AEDs ...
Treatment of epilepsy should begin with a single
antiepileptic drug (AED), increasing its dosage
gradually until seizures are controlled or adverse
effects become intolerable. If seizures persist,
specialists generally recommend trying at least
one and sometimes a second alternative drug as
monotherapy before considering use of two drugs
concurrently. When used for the appropriate seizure
type, AEDs are roughly equivalent in efficacy. Drug
choice is usually based on factors such as ease of
use, adverse effects, drug interactions, presence of
comorbidities, and cost.
Antifungal Drugs
Treatment Guidelines from The Medical Letter • Aug 01, 2012 (Issue 120)
and potential for drug-drug interactions.
FLUCONAZOLE — Fluconazole (Diflucan, and
others) is active against ...
The drugs of choice for treatment of fungal infections
are listed in the table that begins on page 62. Some of
the indications and dosages recommended here have
not been approved by the FDA. More detailed guidelines
for some of these infections are available online
from the Infectious Diseases Society of America
(www.idsociety.org).