Search Results for "Chemotherapy"
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Searched for Chemotherapy. Results 71 to 80 of 220 total matches.
Adagrasib (Krazati) for Colorectal Cancer (online only)
The Medical Letter on Drugs and Therapeutics • Aug 19, 2024 (Issue 1709)
fluoropyrimidine-,
oxaliplatin-, and irinotecan-based chemotherapy.1
Adagrasib is the first KRAS inhibitor ...
The RAS GTPase family inhibitor adagrasib (Krazati –
BMS), which received accelerated approval for
treatment of KRAS G12C (glycine-to-cysteine mutation
at codon 12)-mutated locally advanced or metastatic
non-small cell lung cancer (NSCLC) in 2022, has now
received accelerated approval from the FDA for use
with cetuximab for treatment of KRAS G12C-mutated
locally advanced or metastatic colorectal cancer
(CRC) in adults who received prior fluoropyrimidine-,
oxaliplatin-, and irinotecan-based chemotherapy.
Adagrasib is the first KRAS inhibitor to be approved in
the US for treatment...
Med Lett Drugs Ther. 2024 Aug 19;66(1709):e137-8 doi:10.58347/tml.2024.1709f | Show Introduction Hide Introduction
Temozolomide for Refractory Anaplastic Astrocytoma
The Medical Letter on Drugs and Therapeutics • Dec 17, 1999 (Issue 1068)
gliomas is surgical resection
followed by cranial irradiation. Further treatment with chemotherapy ...
Temozolomide has received accelerated approval from the FDA for oral treatment of adults with anaplastic astrocytoma that has relapsed after treatment with a nitrosourea (lomustine or carmustine) and procarbazine.
Bortezomib (Velcade) for Multiple Myeloma
The Medical Letter on Drugs and Therapeutics • Jul 21, 2003 (Issue 1161)
steroids, chemotherapy and stem cell transplantation (A Kumar et al, Lancet Oncol 2003; 4:293). None ...
Bortezomib (PS341; Velcade Millenium), the first proteasome inhibitor, has received accelerated approval from the FDA for treatment of refractory multiple myeloma. This review includes descriptions of the mechanism of action, pharmacokinetics, adverse effects, and dosage and cost of bortezomib, outlines the results of clinical studies, and concludes with an overall assessment of the drug's effectiveness.
Inotuzumab Ozogamicin (Besponsa) - An Antibody-Drug Conjugate for ALL (online only)
The Medical Letter on Drugs and Therapeutics • May 21, 2018 (Issue 1547)
Besponsa: beh spon’ suh
RELAPSED OR REFRACTORY ALL — Induction
chemotherapy induces a complete remission ...
The FDA has approved inotuzumab ozogamicin
(Besponsa – Pfizer), a humanized anti-CD22
monoclonal antibody conjugated to the cytotoxic
antibiotic calicheamicin, for treatment of relapsed
or refractory B-cell precursor acute lymphoblastic
leukemia (ALL) in adults. It is the first CD22-directed
antibody-drug conjugate to be approved in the US.
In Brief: Brentuximab Vedotin (Adcetris) for Classical Hodgkin's Lymphoma (online only)
The Medical Letter on Drugs and Therapeutics • Nov 05, 2018 (Issue 1559)
in combination with chemotherapy for IV treatment
of adults with previously untreated stage 3 or 4 classical ...
The FDA has approved the anti-CD30 antibody-drug conjugate brentuximab vedotin (Adcetris – Seattle Genetics) for use in combination with chemotherapy for IV treatment of adults with previously untreated stage 3 or 4 classical Hodgkin's lymphoma (cHL). Adcetris was approved earlier for consolidation treatment of cHL and for treatment of relapsed or refractory cHL, anaplastic large cell lymphoma, and CD30-expressing mycosis fungoides.FDA approval for the new indication was based on the results of an open-label trial (ECHELON-1) in 1334 patients with previously untreated stage 3 or 4 cHL.1...
Erythropoietin (Procrit; Epogen) Revisited
The Medical Letter on Drugs and Therapeutics • May 14, 2001 (Issue 1104)
to chronic renal failure, cancer chemotherapy
or HIV treatment, and before elective non-cardiac surgery ...
Use of epoetin alfa, a recombinant human erythropoietin, is being promoted directly to consumers in vague advertisements that promise renewed energy and improved work capacity. Epoetin is approved by the FDA for treatment of anemia due to chronic renal failure, cancer chemotherapy or HIV treatment, and before elective non-cardiac surgery. It is also used illicitly by competitive athletes to increase their endurance.
Ibritumomab Tiuxetan (Zevalin) for Non-Hodgkin's Lymphoma
The Medical Letter on Drugs and Therapeutics • Nov 25, 2002 (Issue 1144)
. Standard therapy has included
conventional external radiation and chemotherapy. Most recently ...
Yttrium-90 ibritumomab tiuxetan (Zevalin -IDEC) was approved by the FDA for treatment of patients with relapsed or refractory low-grade follicular or transformed B-cell non-Hodgkin's lymphoma (NHL), including patients with follicular lymphoma refractory to rituximab (Rituxan -Medical Letter 1998; 40:65). Zevalin is the first radioimmunoconjugate to be approved for treatment of cancer.
Tisagenlecleucel (Kymriah) for ALL
The Medical Letter on Drugs and Therapeutics • Oct 23, 2017 (Issue 1532)
. About 80% of children respond to
first-line chemotherapy, but if leukemia recurs, it is
less ...
The FDA has approved tisagenlecleucel (Kymriah —
Novartis), an individualized, genetically-modified
cellular product, for treatment of relapsed or refractory
B-cell precursor acute lymphoblastic leukemia (ALL)
in patients ≤25 years old. The patient's own T cells
are genetically modified to express chimeric antigen
receptors (CAR) and then reinfused. Kymriah is the
first CAR T-cell immunotherapy to become available in
the US. A CAR T-cell product for B-cell non-Hodgkin's
lymphoma is expected to be approved soon.
Axicabtagene Ciloleucel (Yescarta) for B-Cell Lymphoma (online only)
The Medical Letter on Drugs and Therapeutics • Jul 16, 2018 (Issue 1551)
of non-Hodgkin lymphoma, respond to
chemotherapy (CHOP; cyclophosphamide, doxorubicin,
vincristine ...
The FDA has approved axicabtagene ciloleucel
(Yescarta – Kite) for treatment of adults with relapsed
or refractory CD19+ large B-cell lymphoma after ≥2
lines of systemic therapy. Yescarta is an individualized
cellular product prepared from the patient's own T cells,
which are genetically modified to express chimeric
antigen receptors (CAR) and then infused back into
the patient. It is the second CAR T-cell immunotherapy
to become available in the US. Tisagenlecleucel
(Kymriah), a CAR T-cell product previously approved
for treatment of relapsed or refractory B-cell...
Idecabtagene Vicleucel (Abecma) for Multiple Myeloma (online only)
The Medical Letter on Drugs and Therapeutics • Nov 14, 2022 (Issue 1663)
lymphodepleting chemotherapy
(fludarabine 30 mg/m2 and cyclophosphamide
300 mg/m2, both IV once daily for 3 days ...
The FDA has approved idecabtagene vicleucel
(Abecma – BMS), a B-cell maturation antigen (BCMA)-directed genetically-modified cellular product, for
treatment of relapsed or refractory multiple myeloma in
adults who received ≥4 prior lines of therapy, including
a proteasome inhibitor, an immunomodulatory drug,
and an anti-CD38 monoclonal antibody. Abecma is
an individualized cellular product prepared from the
patient’s own T cells, which are genetically modified
to express chimeric antigen receptors (CAR) and
then infused back into the patient. Ciltacabtagene
autoleucel...