The Medical Letter on Drugs and Therapeutics
Update: Influenza Resistance to Amantadine and Rimantadine
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Med Lett Drugs Ther. 2006 Jan 30;48(1227):12
 Select a term to see related articles  Amantadine   antiviral resistance   antivirals   cdc health alert   flu   flu resistance   Flumadine   health alert   influenza   influenza resistance   resistance   Rimantadine   Symmetrel 

Our article on Antiviral Drugs for Prophylaxis and Treatment of Influenza (Med Lett Drugs Ther 2005;47:93) mentioned possible use of amantadine (Symmetrel, and others) and rimantadine (Flumadine, and others), but warned that the incidence of resistance has increased substantially. The CDC recently issued a Health Alert ( saying that current evidence indicates that a high proportion of circulating influenza A viruses in the US are now resistant to amantadine and rimantadine and they should not be used for this indication, at least this year.

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