Our recent article entitled Lumateperone (Caplyta) for Adjunctive Treatment of Depression1 should have included urinary incontinence among the adverse effects associated with use of second-generation antipsychotic drugs. Urinary incontinence has been reported with both first- and second-generation antipsychotics. Possible causes include the anti-alpha-adrenergic, antidopaminergic, and anticholinergic effects of these drugs, as well as sedation. In an observational study in 200 women 20-40 years old, urinary incontinence was reported by 29% of those taking antipsychotic drugs and by 13% of age-matched controls.2

1. Med Lett Drugs Ther 2026; 68:20.
2. L Yosef et al. Antipsychotic treatment influence on urinary incontinence in young women-types, severity and life quality. Eur J Obstet Gynecol Reprod Biol 2025; 309:214. doi:10.1016/j.ejogrb.2025.03.020