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Nivolumab (Opdivo) for Metastatic Melanoma and Metastatic NSCLC

   
The Medical Letter on Drugs and Therapeutics • Jun 08, 2015  (Issue 1470)
death receptor-1 (PD-1) blocking antibody, for treatment of unresectable or metastatic melanoma ...
The FDA has approved nivolumab (Opdivo – BMS), an IV programmed death receptor-1 (PD-1) blocking antibody, for treatment of unresectable or metastatic melanoma that has progressed following treatment with ipilimumab (and a BRAF inhibitor in patients who are BRAF V600 mutation positive) and for treatment of metastatic squamous non-small cell lung cancer (NSCLC) that has progressed on or after platinum-based chemotherapy. It is the second PD-1 inhibitor to be marketed in the US after pembrolizumab (Keytruda), and the first to be approved for treatment of NSCLC.
Med Lett Drugs Ther. 2015 Jun 8;57(1470):85-7 | Show Introduction Hide Introduction

Two New Drugs for Glaucoma

   
The Medical Letter on Drugs and Therapeutics • Jul 16, 2018  (Issue 1551)
effective and may be better tolerated. The 0.1% formulation of the drug is better tolerated than higher ...
The FDA has approved two new ophthalmic drugs for reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension: latanoprostene bunod (Vyzulta – Bausch and Lomb), a modified prostaglandin analog, and netarsudil (VRhopressa – Aerie), the first Rho kinase inhibitor to be approved in the US.
Med Lett Drugs Ther. 2018 Jul 16;60(1551):117-20 | Show Introduction Hide Introduction

Oat Bran for Lowering Blood Lipids

   
The Medical Letter on Drugs and Therapeutics • Dec 02, 1988  (Issue 780)
effect than insoluble fiber (IM Ullrich, J Am Coll Nutr, 1:19, 1987). The mechanism of action ...
Oat bran, the ground inner husk of the grain, has recently become popular as a dietary means of lowering blood lipids. It is available both separately and as a constituent of oatmeal, which is the ground product of the whole grain. Oat bran and oatmeal are available in various breakfast cereals and can also be used in baked goods, such as muffins or bread. Some of these sources are listed in the table on page 112.
Med Lett Drugs Ther. 1988 Dec 2;30(780):111-2 | Show Introduction Hide Introduction

Minocycline Foam (Zilxi) for Rosacea

   
The Medical Letter on Drugs and Therapeutics • Nov 16, 2020  (Issue 1611)
Minocycline Foam (Zilxi) for Rosacea The FDA has approved a 1.5% topical foam formulation ...
The FDA has approved a 1.5% topical foam formulation of minocycline (Zilxi – Foamix) for treatment of inflammatory lesions of rosacea in adults. It is the only topical minocycline product approved for this indication. The same manufacturer markets minocycline foam 4% (Amzeeq) for treatment of acne in patients ≥9 years old.
Med Lett Drugs Ther. 2020 Nov 16;62(1611):179-80 | Show Introduction Hide Introduction

Semaglutide (Ozempic) for Weight Loss

   
The Medical Letter on Drugs and Therapeutics • Apr 05, 2021  (Issue 1621)
subcutaneous injection of the glucagon-like peptide 1 (GLP-1) receptor agonist semaglutide (Ozempic – Novo ...
In recently published clinical trials, once-weekly subcutaneous injection of the glucagon-like peptide 1 (GLP-1) receptor agonist semaglutide (Ozempic – Novo Nordisk), which is FDA-approved for treatment of type 2 diabetes and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, has reduced body weight significantly in patients with and without type 2 diabetes when given in addition to lifestyle intervention. Liraglutide (Saxenda), another GLP-1 receptor agonist, has been FDA-approved for chronic weight...
Med Lett Drugs Ther. 2021 Apr 5;63(1621):53-4 | Show Introduction Hide Introduction

Cariprazine (Vraylar) for Schizophrenia and Bipolar I Disorder

   
The Medical Letter on Drugs and Therapeutics • Apr 25, 2016  (Issue 1493)
Table 1. Pharmacology Class Second-generation antipsychotic Mechanism Dopamine (D2) and serotonin (5 ...
The FDA has approved cariprazine (Vraylar – Actavis), an oral, once-daily, second-generation antipsychotic, for treatment of schizophrenia and for acute treatment of manic or mixed episodes associated with bipolar I disorder.
Med Lett Drugs Ther. 2016 Apr 25;58(1493):51-3 | Show Introduction Hide Introduction

Low-Dose Sublingual Zolpidem (Intermezzo) for Insomnia due to Middle-of-the-Night Awakening

   
The Medical Letter on Drugs and Therapeutics • Apr 02, 2012  (Issue 1387)
, both doses (1.75 and 3.5 mg) of the new formulation produced plasma concentrations >20 ng/mL ...
The FDA has approved a new low-dose sublingual tablet formulation of the benzodiazepine receptor agonist zolpidem tartrate (Intermezzo – Transcept/Purdue) for treatment of insomnia due to middle-of-the-night awakening. Ambien and other zolpidem formulations available in the US are labeled for use only at bedtime.
Med Lett Drugs Ther. 2012 Apr 2;54(1387):25-6 | Show Introduction Hide Introduction

Obinutuzumab (Gazyva) for Chronic Lymphocytic Leukemia (online only)

   
The Medical Letter on Drugs and Therapeutics • Nov 10, 2014  (Issue 1455)
(CLL). Two other anti-CD20 antibodies, rituximab (Rituxan) and ofatumumab (Arzerra),1 were previously ...
Obinutuzumab (Gazyva – Genentech), a humanized anti-CD20 monoclonal antibody, has been approved by the FDA for use in combination with chlorambucil (Leukeran) in patients with previously untreated chronic lymphocytic leukemia (CLL). Two other anti-CD20 antibodies, rituximab (Rituxan) and ofatumumab (Arzerra), were previously approved for treatment of CLL.
Med Lett Drugs Ther. 2014 Nov 10;56(1455):e114-5 | Show Introduction Hide Introduction

Ivermectin Cream (Soolantra) for Rosacea

   
The Medical Letter on Drugs and Therapeutics • Apr 13, 2015  (Issue 1466)
' tra The FDA has approved a 1% cream formulation of the antiparasitic drug ivermectin (Soolantra ...
The FDA has approved a 1% cream formulation of the antiparasitic drug ivermectin (Soolantra – Galderma) for topical treatment of inflammatory lesions of rosacea. Ivermectin is available in the US in tablets (Stromectol, and generics) for treatment of onchocerciasis and other worm infestations and as a 0.5% lotion (Sklice) for treatment of head lice.
Med Lett Drugs Ther. 2015 Apr 13;57(1466):51-2 | Show Introduction Hide Introduction

Levalbuterol for Asthma

   
The Medical Letter on Drugs and Therapeutics • Jun 04, 1999  (Issue 1054)
. PHARMACOLOGY — Albuterol is a racemic mixture with a 1:1 ratio of the isomers R-albuterol (levalbuterol ...
Levalbuterol, the R-isomer of racemic albuterol, has been approved by the FDA for prevention and treatment of bronchospasm in patients at least 12 years old.
Med Lett Drugs Ther. 1999 Jun 4;41(1054):51-3 | Show Introduction Hide Introduction