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Siponimod (Mayzent) - A New Drug for Multiple Sclerosis
The Medical Letter on Drugs and Therapeutics • May 06, 2019 (Issue 1571)
–
Novartis), a sphingosine 1-phosphate (S1P) receptor
modulator, for oral treatment of adults with relapsing ...
The FDA has approved siponimod (Mayzent –
Novartis), a sphingosine 1-phosphate (S1P) receptor
modulator, for oral treatment of adults with relapsing
forms of multiple sclerosis (MS), including clinically
isolated syndrome (initial neurological episode),
relapsing-remitting disease, and active secondary
progressive MS (SPMS). Siponimod is the second
S1P receptor modulator to be approved in the US;
fingolimod (Gilenya), which is approved for oral
treatment of relapsing forms of MS in patients ≥10
years old, was the first. The purine antimetabolite
cladribine (Mavenclad) was also...
Generic Topical Corticosteroids
The Medical Letter on Drugs and Therapeutics • May 06, 1988 (Issue 765)
(Volume 28, page 1, 1986), the prediction
that generic drugs newly approved in the USA under more relaxed ...
Since the last Medical Letter review of generic drugs (Volume 28, page 1, 1986), the prediction that generic drugs newly approved in the USA under more relaxed federal regulations will probably be as reliable as brand-name drugs has generally been accurate. Few well-documented generic product failures have been reported. Recently, however, the equivalence of generic topical corticosteroids has been questioned.
Another Extended-Release Alpha2-Agonist for ADHD
The Medical Letter on Drugs and Therapeutics • Feb 07, 2011 (Issue 1357)
for this indication;
guanfacine hydrochloride (Intuniv) was the first,1 but
only clonidine is approved for use ...
The FDA has approved an extended-release formulation of clonidine hydrochloride (Kapvay– Shionogi) for treatment of attention-deficit/hyperactivity disorder (ADHD) in children 6-17 years old. It is the second alpha2-adrenergic agonist approved for this indication; guanfacine hydrochloride (Intuniv) was the first, but only clonidine is approved for use with stimulants.
Terconazole For Candida Vaginitis
The Medical Letter on Drugs and Therapeutics • Dec 30, 1988 (Issue 782)
in plasma (BF Kennedy and H Friedmann, Gynakol Rundsch, 25 suppl 1:26, 1985).
ANTIMICROBIAL ACTIVITY ...
Terconazole (Terazol - Ortho), an imidazole derivative, was recently marketed in the USA for treatment of vulvovaginal candidiasis. It is available both as a 0.4% vaginal cream (Terazol 7) and in 80-mg vaginal suppositories (Terazol 3).
Glucagon Nasal Powder (Baqsimi) for Severe Hypoglycemia
The Medical Letter on Drugs and Therapeutics • Sep 23, 2019 (Issue 1581)
see' mee
SEVERE HYPOGLYCEMIA – Hypoglycemia is
classified as level 1 (blood glucose ≥54 and ...
The FDA has approved glucagon nasal powder
(Baqsimi – Lilly) for treatment of severe hypoglycemia
in patients ≥4 years old with diabetes. Baqsimi is the
first noninjectable glucagon formulation to become
available in the US. Injectable glucagon emergency kits
(GlucaGen Hypokit, and generic) have been available
for years, but they require reconstitution of the
lyophilized powder by the caregiver immediately before
injection. An injectable glucagon formulation that does
not require reconstitution was recently approved by the
FDA (Gvoke) and is expected to become available...
In Brief: New Meningococcal Serogroup B Vaccination Recommendations
The Medical Letter on Drugs and Therapeutics • Nov 30, 2020 (Issue 1612)
on Immunization Practices
(ACIP) has issued new recommendations for meningococcal
vaccination.1 Booster ...
The Advisory Committee on Immunization Practices
(ACIP) has issued new recommendations for meningococcal
vaccination. Booster vaccination against
Neisseria meningitidis serogroup B (MenB) is
now recommended in persons at increased risk
for meningococcal disease (see Table 1). MenB
booster doses were not recommended previously for
any population.
Linagliptin/Metformin (Jentadueto) for Type 2 Diabetes
The Medical Letter on Drugs and Therapeutics • May 14, 2012 (Issue 1390)
require treatment with multiple drugs.1 Linagliptin is
a dipeptidyl peptidase-4 (DDP-4) inhibitor like ...
Linagliptin (Tradjenta) and metformin (Glucophage,
and others) are now available as a fixed-dose combination
(Jentadueto – Boehringer Ingelheim/Lilly) for
oral treatment of type 2 diabetes in adults. Metformin
is generally the preferred first-line agent for treatment
of type 2 diabetes, but most patients eventually
require treatment with multiple drugs. Linagliptin is
a dipeptidyl peptidase-4 (DDP-4) inhibitor like
sitagliptin (Januvia) and saxagliptin (Onglyza). Both
sitagliptin and saxagliptin are also available in fixed-dose
combinations with...
Simeprevir (Olysio) for Chronic Hepatitis C
The Medical Letter on Drugs and Therapeutics • Jan 06, 2014 (Issue 1433)
COPYRIGHT LAWS 1
The FDA has recently approved 2 new drugs for treatment
of chronic hepatitis C virus (HCV ...
The FDA has recently approved 2 new drugs for treatment of chronic hepatitis C virus (HCV) infection. Simeprevir (Olysio – Janssen) is the third oral protease inhibitor to be approved for use in combination with peginterferon and ribavirin for treatment of chronic HCV genotype 1 infection in adults with compensated liver disease. Telaprevir (Incivek) and boceprevir (Victrelis) were approved in 2011 for the same indication. Sofosbuvir (Sovaldi – Gilead), a nucleotide analog polymerase inhibitor that has been approved for use with and without interferon for treatment of multiple HCV...
Cetirizine Ophthalmic Solution (Zerviate) for Allergic Conjunctivitis
The Medical Letter on Drugs and Therapeutics • Jun 01, 2020 (Issue 1599)
compresses, and avoidance of eye rubbing and contact
lens wearing during symptomatic periods.1
Many ...
A 0.24% ophthalmic solution of the second-generation
H1-antihistamine cetirizine (Zerviate – Eyevance) is now
available by prescription for treatment of ocular itching
associated with allergic conjunctivitis in patients ≥2
years old. Oral cetirizine (Zyrtec, and others), which is
used for treatment of allergic conjunctivitis and rhinitis,
has been available over the counter (OTC) for years.
Tapinarof Cream (Vtama) for Psoriasis
The Medical Letter on Drugs and Therapeutics • Jun 22, 2022 (Issue 5049)
' uh
The FDA has approved Vtama (Dermavant), a 1%
cream formulation of the aryl hydrocarbon receptor ...
The FDA has approved Vtama (Dermavant), a 1%
cream formulation of the aryl hydrocarbon receptor
(AhR) agonist tapinarof, for treatment of adults with
plaque psoriasis. It is the first AhR agonist to be
approved by the FDA.