Search Results for "Drug Interactions"
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Searched for Drug Interactions. Results 241 to 250 of 281 total matches.
Jornay PM - Evening-Dosed Methylphenidate for ADHD
The Medical Letter on Drugs and Therapeutics • Aug 12, 2019 (Issue 1578)
-term
studies are lacking.
DRUG INTERACTIONS – Concurrent use of CNS
stimulants ...
The FDA has approved Jornay PM (Ironshore), a
capsule formulation of methylphenidate with a
delayed-release outer layer and an extended-release
inner layer, for once-nightly treatment of attention-deficit hyperactivity disorder (ADHD) in patients >6
years old. Jornay PM is the first methylphenidate
product to become available in the US that is taken
in the evening; other long-acting methylphenidate
formulations are taken in the morning. It is being
marketed specifically for patients who have disruptive
ADHD symptoms in the morning.
Bempedoic Acid (Nexletol) for Lowering LDL-Cholesterol
The Medical Letter on Drugs and Therapeutics • Apr 06, 2020 (Issue 1595)
.
DRUG INTERACTIONS — Coadministration of
bempedoic acid and simvastatin or pravastatin
increases serum ...
The FDA has approved the oral adenosine triphosphate-citrate
lyase (ACL) inhibitor bempedoic acid for
use alone (Nexletol – Esperion) and in a fixed-dose
combination with the cholesterol absorption inhibitor
ezetimibe (Nexlizet) as an adjunct to diet and maximally
tolerated statin therapy in adults with heterozygous
familial hypercholesterolemia (HeFH) or established
atherosclerotic cardiovascular disease (ASCVD) who
require additional lowering of LDL-cholesterol (LDL-C).
Bempedoic acid is the first ACL inhibitor to be approved
in the US.
Upadacitinib (Rinvoq): A Second JAK Inhibitor for Ulcerative Colitis
The Medical Letter on Drugs and Therapeutics • Sep 05, 2022 (Issue 1658)
.8,9
DRUG INTERACTIONS — Upadacitinib is metabolized
primarily by CYP3A4 and to a minor extent ...
The FDA has approved the oral Janus kinase (JAK)
inhibitor upadacitinib (Rinvoq – Abbvie) for treatment
of moderately to severely active ulcerative colitis in
adults who have had an inadequate response to or
cannot tolerate one or more tumor necrosis factor
(TNF) inhibitors. Upadacitinib is the second JAK
inhibitor to be approved for this indication; tofacitinib
(Xeljanz) was the first. Upadacitinib is also approved
for treatment of rheumatoid arthritis, psoriatic
arthritis, atopic dermatitis, and ankylosing spondylitis.
Tenapanor (Ibsrela) for Irritable Bowel Syndrome with Constipation
The Medical Letter on Drugs and Therapeutics • Jun 13, 2022 (Issue 1652)
infant.
DRUG INTERACTIONS — Tenapanor is an inhibitor of
organic anion transporting polypeptide (OATP ...
The FDA has approved tenapanor (Ibsrela - Ardelyx),
a sodium/hydrogen exchanger 3 (NHE3) inhibitor, for
twice-daily oral treatment of irritable bowel syndrome
with constipation (IBS-C) in adults. Tenapanor is the
first NHE3 inhibitor to become available in the US.
IV Meloxicam (Anjeso) for Pain
The Medical Letter on Drugs and Therapeutics • Jun 29, 2020 (Issue 1601)
of lactating rats at concentrations
greater than those in plasma.
DRUG INTERACTIONS — NSAIDs may decrease ...
The FDA has approved Anjeso (Baudax Bio), an IV
formulation of the nonsteroidal anti-inflammatory
drug (NSAID) meloxicam, for once-daily treatment
of moderate to severe pain in adults. Oral meloxicam
(Mobic, and others), which is only indicated
for treatment of chronic pain associated with
osteoarthritis or rheumatoid arthritis, has been
available for 20 years. IV formulations of ketorolac,
ibuprofen (Caldolor), and acetaminophen (Ofirmev)
are also available for treatment of pain.
Sotatercept (Winrevair) for Pulmonary Arterial Hypertension
The Medical Letter on Drugs and Therapeutics • May 13, 2024 (Issue 1702)
events in adults with WHO Group 1 pulmonary arterial
hypertension (PAH).
STANDARD TREATMENT — Drugs ...
The FDA has approved sotatercept-csrk (Winrevair –
Merck), a first-in-class activin signaling inhibitor, to
increase exercise capacity, improve WHO functional
class, and reduce the risk of clinical worsening
events in adults with WHO Group 1 pulmonary arterial
hypertension (PAH).
Med Lett Drugs Ther. 2024 May 13;66(1702):73-5 doi:10.58347/tml.2024.1702a | Show Introduction Hide Introduction
Opicapone (Ongentys) - A COMT Inhibitor for Parkinson's Disease
The Medical Letter on Drugs and Therapeutics • Jan 11, 2021 (Issue 1615)
with pheochromocytoma, paraganglioma, or other
catecholamine-secreting neoplasms.
DRUG INTERACTIONS — Coadministration ...
The FDA has approved opicapone (Ongentys –
Neurocrine), a peripherally-acting reversible catechol-O-methyltransferase (COMT) inhibitor, for oral use as an
adjunct to carbidopa/levodopa in adults with Parkinson’s
disease (PD) who experience "off" episodes. It is the
third COMT inhibitor to be approved for this indication;
tolcapone (Tasmar, and generics) and entacapone
(Comtan, and generics) were approved earlier. Opicapone
has been available in Europe since 2016.
Bexagliflozin (Brenzavvy) — A Fifth SGLT2 Inhibitor for Type 2 Diabetes
The Medical Letter on Drugs and Therapeutics • Aug 21, 2023 (Issue 1683)
are available.
DRUG INTERACTIONS — Bexagliflozin is metabolized
primarily by UDP-glucuronosyltransferase
(UGT ...
Bexagliflozin (Brenzavvy – TheracosBio), a sodium-glucose
cotransporter 2 (SGLT2) inhibitor, has been
approved by the FDA to improve glycemic control
in adults with type 2 diabetes. It is the fifth SGLT2
inhibitor to be approved in the US for this indication
(see Table 4).
Med Lett Drugs Ther. 2023 Aug 21;65(1683):130-2 doi:10.58347/tml.2023.1683b | Show Introduction Hide Introduction
Tirzepatide (Mounjaro) for Type 2 Diabetes
The Medical Letter on Drugs and Therapeutics • Jul 11, 2022 (Issue 1654)
.
DRUG INTERACTIONS ― Tirzepatide delays gastric
emptying and can delay the absorption of oral drugs ...
The FDA has approved tirzepatide (Mounjaro –
Lilly), a peptide hormone with activity at both
glucose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide-1 (GLP-1)
receptors, to improve glycemic control in adults
with type 2 diabetes. Tirzepatide, which is injected
subcutaneously once weekly, is the first dual GIP/GLP-1 receptor agonist to become available in the
US. Selective GIP receptor agonists are not available
in the US; GLP-1 receptor agonists have been
available for years.
Airsupra: An Inhaled Albuterol/Budesonide Combination for Asthma
The Medical Letter on Drugs and Therapeutics • Mar 18, 2024 (Issue 1698)
. Cataracts, glaucoma, and decreased
bone mineral density have been observed with longterm
use.
DRUG ...
The FDA has approved Airsupra (AstraZeneca), a
metered-dose inhaler containing the short-acting
beta2-agonist (SABA) albuterol and the inhaled
corticosteroid (ICS) budesonide, for use as needed for
treatment or prevention of bronchoconstriction and to
reduce the risk of exacerbations in patients ≥18 years
old with asthma. Airsupra is the first combination of
a SABA and an ICS to become available in the US. It is
not approved for use as maintenance therapy.
Med Lett Drugs Ther. 2024 Mar 18;66(1698):41-3 doi:10.58347/tml.2024.1698a | Show Introduction Hide Introduction