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Melatonin
The Medical Letter on Drugs and Therapeutics • Nov 24, 1995 (Issue 962)
healthy volunteers, 0.3 or 1 mg of melatonin (Nestle, Switzerland) taken during the day produced serum ...
Several readers have asked the Medical Letter to evaluate the effectiveness and safety of exogenous melatonin for treatment of insomnia and jet lag. Melatonin has not been approved by the US Food and Drug Administration (FDA), but is available in health food stores and apparently is being used as self-medication to treat a wide variety of disorders.
Topiramate for Epilepsy
The Medical Letter on Drugs and Therapeutics • May 23, 1997 (Issue 1001)
have
been reported. In clinical trials, renal stones occurred in 1.5% of patients (SD Shorvon, Epilepsia,
37 suppl 2 ...
Topiramate (Topamax - Ortho-McNeil) has been approved by the US Food and Drug Administration (FDA) for oral use as an adjunct to other drugs in adult patients with partial seizures. Since this diagnostic category includes the largest number of patients with refractory epilepsy, new drugs with antiepileptic activity are usually tried first for this indication. Topiramate (toe pyre' a mate) is a structurally unique agent chemically related to the D-enantiomer of fructose.
Fenofibrate for Hypertriglyceridemia
The Medical Letter on Drugs and Therapeutics • Jul 03, 1998 (Issue 1030)
them by about 30%
to 50%, and produced slightly greater increases (1% to 34%) in HDL cholesterol (JC ...
Micronized fenofibrate (Tricor - Abbott), a fibric acid derivative structurally similar to clofibrate (Atromid-S, and others) and gemfibrozil (Lopid, and others), has been approved by the FDA for treatment of hypertriglyceridemia. Increased serum triglyceride concentrations have been associated with an increased risk of coronary heart disease (J Jeppesen et al, Circulation, 97:1029, 1998).
Infliximab (Remicade) for Crohn's Disease
The Medical Letter on Drugs and Therapeutics • Feb 26, 1999 (Issue 1047)
mg/kg of the drug, 13 (48%) went into remission, compared to 1 of 25 (4%) of those given
placebo ...
Infliximab, a monoclonal antibody that inhibits tumor necrosis factor, has received an accelerated approval from the FDA for intravenous treatment of moderate to severe Crohn's disease refractory to other medical treatment.
Laser Hair Removal
The Medical Letter on Drugs and Therapeutics • Jul 30, 1999 (Issue 1058)
Aesth Dermatol Cosmet Surg, 1:3, 1999).
MECHANISM OF ACTION — Several laser systems are used for hair ...
A long-pulse ruby laser (EpiLaser), has been cleared by the FDA for use in "permanent hair reduction."
Phytoestrogens
The Medical Letter on Drugs and Therapeutics • Feb 21, 2000 (Issue 1072)
at 1000 Main Street, New Rochelle, NY
10801-7537. Subscription fees: 1 year, $49.00; 2 years, $82.00; 3 ...
Phytoestrogens, plant compounds that are converted to estrogens in the gut, are widely promoted as "natural"substitutes for estrogen in hormone replacement therapy.
Update on Glucosamine For Osteoarthritis
The Medical Letter on Drugs and Therapeutics • Dec 10, 2001 (Issue 1120)
10801-7537. Subscription fees: 1 year, $55.00; 2 years, $94.00; 3 years, $132.00 ($27.50—U.S. Funds—per ...
Since the last Medical Letter article on glucosamine for osteoarthritis (vol.39, page 91, September 26, 1997), more data have become available. Glucosamine is available in US pharmacies and health food stores as sulfate, hydrochloride or n-acetyl salt.
Dexmethylphenidate (Focalin) For ADHD
The Medical Letter on Drugs and Therapeutics • May 13, 2002 (Issue 1130)
Rochelle,
NY 10801-7537. Subscription fees: 1 year, $55.00; 2 years, $94.00; 3 years, $132.00 ($27.50—U.S ...
Dexmethylphenidate (Focalin - Novartis), a new formulation of methylphenidate (Ritalin, and others) is now available for treatment of attention deficit/hyperactivity disorder (ADHD). Dexmethylphenidate is the d-threo-enantiomer of racemic methylphenidate. "Now the right half may be all your patients need," said a recent ad. Focalin is the third new methylphenidate formulation marketed in the last two years.
Beta Interferons for Multiple Sclerosis
The Medical Letter on Drugs and Therapeutics • Oct 14, 2002 (Issue 1141)
BETA INTERFERONS FOR MS
Drug Dosage Cost
1
Interferon β-1a − Avonex (Biogen) 30 µg weekly IM $12,808 ...
Three beta interferons are widely used in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS).
Rasburicase (Elitek) for Hyperuricemia
The Medical Letter on Drugs and Therapeutics • Nov 11, 2002 (Issue 1143)
*
Allopurinol
generic 150-300 mg PO $ 1.82
Zyloprim (Prometheus) 2.20
Aloprim (Nabi) 200 mg/m
2
IV 1290.00 ...
Rasburicase (Elitek - Sanofi-Synthelabo), a recombinant form of urate oxidase derived from the fungus Aspergillus flavus, has been approved by the FDA for intravenous (IV) management of hyperuricemia associated with tumor lysis syndrome in pediatric patients.