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Melatonin

   
The Medical Letter on Drugs and Therapeutics • Nov 24, 1995  (Issue 962)
healthy volunteers, 0.3 or 1 mg of melatonin (Nestle, Switzerland) taken during the day produced serum ...
Several readers have asked the Medical Letter to evaluate the effectiveness and safety of exogenous melatonin for treatment of insomnia and jet lag. Melatonin has not been approved by the US Food and Drug Administration (FDA), but is available in health food stores and apparently is being used as self-medication to treat a wide variety of disorders.
Med Lett Drugs Ther. 1995 Nov 24;37(962):111-2 |  Show IntroductionHide Introduction

Topiramate for Epilepsy

   
The Medical Letter on Drugs and Therapeutics • May 23, 1997  (Issue 1001)
have been reported. In clinical trials, renal stones occurred in 1.5% of patients (SD Shorvon, Epilepsia, 37 suppl 2 ...
Topiramate (Topamax - Ortho-McNeil) has been approved by the US Food and Drug Administration (FDA) for oral use as an adjunct to other drugs in adult patients with partial seizures. Since this diagnostic category includes the largest number of patients with refractory epilepsy, new drugs with antiepileptic activity are usually tried first for this indication. Topiramate (toe pyre' a mate) is a structurally unique agent chemically related to the D-enantiomer of fructose.
Med Lett Drugs Ther. 1997 May 23;39(1001):51-2 |  Show IntroductionHide Introduction

Fenofibrate for Hypertriglyceridemia

   
The Medical Letter on Drugs and Therapeutics • Jul 03, 1998  (Issue 1030)
them by about 30% to 50%, and produced slightly greater increases (1% to 34%) in HDL cholesterol (JC ...
Micronized fenofibrate (Tricor - Abbott), a fibric acid derivative structurally similar to clofibrate (Atromid-S, and others) and gemfibrozil (Lopid, and others), has been approved by the FDA for treatment of hypertriglyceridemia. Increased serum triglyceride concentrations have been associated with an increased risk of coronary heart disease (J Jeppesen et al, Circulation, 97:1029, 1998).
Med Lett Drugs Ther. 1998 Jul 3;40(1030):68-9 |  Show IntroductionHide Introduction

Infliximab (Remicade) for Crohn's Disease

   
The Medical Letter on Drugs and Therapeutics • Feb 26, 1999  (Issue 1047)
mg/kg of the drug, 13 (48%) went into remission, compared to 1 of 25 (4%) of those given placebo ...
Infliximab, a monoclonal antibody that inhibits tumor necrosis factor, has received an accelerated approval from the FDA for intravenous treatment of moderate to severe Crohn's disease refractory to other medical treatment.
Med Lett Drugs Ther. 1999 Feb 26;41(1047):19-20 |  Show IntroductionHide Introduction

Laser Hair Removal

   
The Medical Letter on Drugs and Therapeutics • Jul 30, 1999  (Issue 1058)
Aesth Dermatol Cosmet Surg, 1:3, 1999). MECHANISM OF ACTION — Several laser systems are used for hair ...
A long-pulse ruby laser (EpiLaser), has been cleared by the FDA for use in "permanent hair reduction."
Med Lett Drugs Ther. 1999 Jul 30;41(1058):67-70 |  Show IntroductionHide Introduction

Phytoestrogens

   
The Medical Letter on Drugs and Therapeutics • Feb 21, 2000  (Issue 1072)
at 1000 Main Street, New Rochelle, NY 10801-7537. Subscription fees: 1 year, $49.00; 2 years, $82.00; 3 ...
Phytoestrogens, plant compounds that are converted to estrogens in the gut, are widely promoted as "natural"substitutes for estrogen in hormone replacement therapy.
Med Lett Drugs Ther. 2000 Feb 21;42(1072):17-8 |  Show IntroductionHide Introduction

Update on Glucosamine For Osteoarthritis

   
The Medical Letter on Drugs and Therapeutics • Dec 10, 2001  (Issue 1120)
10801-7537. Subscription fees: 1 year, $55.00; 2 years, $94.00; 3 years, $132.00 ($27.50—U.S. Funds—per ...
Since the last Medical Letter article on glucosamine for osteoarthritis (vol.39, page 91, September 26, 1997), more data have become available. Glucosamine is available in US pharmacies and health food stores as sulfate, hydrochloride or n-acetyl salt.
Med Lett Drugs Ther. 2001 Dec 10;43(1120):111-2 |  Show IntroductionHide Introduction

Dexmethylphenidate (Focalin) For ADHD

   
The Medical Letter on Drugs and Therapeutics • May 13, 2002  (Issue 1130)
Rochelle, NY 10801-7537. Subscription fees: 1 year, $55.00; 2 years, $94.00; 3 years, $132.00 ($27.50—U.S ...
Dexmethylphenidate (Focalin - Novartis), a new formulation of methylphenidate (Ritalin, and others) is now available for treatment of attention deficit/hyperactivity disorder (ADHD). Dexmethylphenidate is the d-threo-enantiomer of racemic methylphenidate. "Now the right half may be all your patients need," said a recent ad. Focalin is the third new methylphenidate formulation marketed in the last two years.
Med Lett Drugs Ther. 2002 May 13;44(1130):45-6 |  Show IntroductionHide Introduction

Beta Interferons for Multiple Sclerosis

   
The Medical Letter on Drugs and Therapeutics • Oct 14, 2002  (Issue 1141)
BETA INTERFERONS FOR MS Drug Dosage Cost 1 Interferon β-1a − Avonex (Biogen) 30 µg weekly IM $12,808 ...
Three beta interferons are widely used in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS).
Med Lett Drugs Ther. 2002 Oct 14;44(1141):88-9 |  Show IntroductionHide Introduction

Rasburicase (Elitek) for Hyperuricemia

   
The Medical Letter on Drugs and Therapeutics • Nov 11, 2002  (Issue 1143)
* Allopurinol generic 150-300 mg PO $ 1.82 Zyloprim (Prometheus) 2.20 Aloprim (Nabi) 200 mg/m 2 IV 1290.00 ...
Rasburicase (Elitek - Sanofi-Synthelabo), a recombinant form of urate oxidase derived from the fungus Aspergillus flavus, has been approved by the FDA for intravenous (IV) management of hyperuricemia associated with tumor lysis syndrome in pediatric patients.
Med Lett Drugs Ther. 2002 Nov 11;44(1143):96-7 |  Show IntroductionHide Introduction