The Medical Letter - 2005
Search or Select article below to purchase. Single article price: $45. Order 3 or more at one time and receive a 10% discount.
Year:    Publication:      2005 Annual Index: U.S. English | Canadian English
January 3, 2005 (Issue 1199)  
  • Acamprosate (Campral) for Alcoholism   
    Acamprosate calcium (Campral - Forest) is now being marketed for oral use to maintain abstinence from alcohol. It has been used in France and other countries since 1989.
  • Antiviral KLEENEX   
    The first commercially available virucidal tissue, KLEENEX Anti-Viral Tissue (Kimberly-Clark), was recently introduced and is being heavily promoted to the general public. Patients may ask...
  • In Brief: Airborne   
    Patients may be asking about Airborne, a dietary supplement that is being heavily promoted for prevention and treatment of colds. It contains 7 herbal extracts, 3 vitamins, 2 amino acids,...
January 17, 2005 (Issue 1200)  
  • Alprazolam (Xanax, and others) Revisited   
    Alprazolam, a short-acting benzodiazepine, is one of the most widely prescribed drugs in the US. It is approved by the FDA for treatment of anxiety and panic disorder. An extended-release...
  • Apomorphine (Apokyn) for Parkinson's Disease   
    Apomorphine (Apokyn - Mylan/Bertek), an injected non-ergot dopamine agonist, was recently approved by the FDA for intermittent subcutaneous (SC) treatment of hypomobility ("off" episodes) in...
  • NSAID Alternatives   
    Patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) may be asking their health care providers if they should continue, and some may be asking for alternatives. For most patients taking...
January 31, 2005 (Issue 1201)  
February 14, 2005 (Issue 1202)  
  • Natalizumab (Tysabri) for Relapsing Multiple Sclerosis   
    Natalizumab, a recombinant humanized monoclonal antibody, has received accelerated approval from the FDA for intravenous treatment of relapsing forms of multiple sclerosis (MS). The beta interferons...
  • Virtual Colonoscopy   
    Currently available techniques for colorectal cancer screening include fecal occult-blood testing, flexible sigmoidoscopy, double contrast barium enema (DCBE) and traditional optical colonoscopy....
  • In Brief: Mucinex   
    Patients may be asking health care providers about the safety and effectiveness of Mucinex (Adams), which is being heavily advertised on television and elsewhere for treatment of respiratory...
  • Addendum: Tramadol as an NSAID Alternative   
    In our January 17 issue, a short article on NSAID alternatives mentioned that tramadol (Ultram, and others), a weak opioid analgesic, could be helpful for some patients. A few readers have...
February 28, 2005 (Issue 1203)  
March 14, 2005 (Issue 1204)  
March 28, 2005 (Issue 1205)  
April 11, 2005 (Issue 1206)  
April 25, 2005 (Issue 1207)  
May 9, 2005 (Issue 1208)  
  • Dehydroepiandrosterone (DHEA)   
    Dehydroepiandrosterone (DHEA), an endogenous adrenal steroid, is marketed as a dietary supplement in the US. It is widely promoted to reverse the effects of aging (loss of muscle, memory and libido)...
  • ARBs and Myocardial Infarction   
    Angiotensin receptor blockers (ARBs) are widely used as an alternative to angiotensin converting enzyme (ACE) inhibitors for treatment of hypertension because they lower blood pressure without...
  • Albumin-Bound Paclitaxel (Abraxane) for Advanced Breast Cancer   
    A new albumin-bound formulation of paclitaxel (Abraxane - American Pharmaceutical Partners) has been approved by the FDA for treatment of metastatic breast cancer after failure of combination...
  • Menactra Supply   
    The recent Medical Letter article on the new conjugated meningococcal vaccine (April 11, 2005) stated that there was a shortage of the vaccine. The manufacturer says that so far there is no...
May 23, 2005 (Issue 1209)  
  • Treatment of Lyme Disease   
    Superseded by The Medical Letter "Treatment of Lyme Disease" - Issue 1494, May 9, 2016Lyme disease in North America is caused by the spirochete Borrelia burgdorferi, which is transmitted to...
  • Pramlintide (Symlin) for Diabetes   
    Pramlintide acetate (Symlin - Amylin Pharmaceuticals), a synthetic analog of human amylin, has been approved by the FDA as adjunctive treatment for patients with type 1 or type 2 diabetes who...
June 6, 2005 (Issue 1210)  
June 20, 2005 (Issue 1211)  
  • Viagra and Loss of Vision   
    The FDA recently announced that it was investigating 38 reports of loss of vision in men who took sildenafil (Viagra), which has been used to treat erectile dysfunction since 1998.
  • Vagus Nerve Stimulation for Depression   
    A device that stimulates the vagus nerve was approved by the FDA in July 1997 for treatment of refractory epilepsy and is now considered "approvable" for treatment-resistant depression.
  • Micafungin (Mycamine) for Fungal Infections   
    Micafungin sodium (Mycamine - Astellas), the second echinocandin antifungal to become available in the US, has been approved by the FDA for intravenous treatment of esophageal candidiasis and...
July 4, 2005 (Issue 1212)  
  • Colonoscopy Preparations   
    Superseded by The Medical Letter "Colonoscopy Preparations" - Issue 1408, January 21, 2013Many patients consider cleansing the bowel in preparation for colonoscopy the most unpleasant part of...
  • CYP3A and Drug Interactions   
    Serious adverse interactions between drugs continue to be reported. Many of these are due to inhibition or induction of cytochrome P450 (CYP) enzymes, particularly CYP3A4. CYP3A is thought to be...
  • Pegaptanib Sodium (Macugen) for Macular Degeneration   
    The FDA has approved pegaptanib sodium (Macugen - Pfizer/Eyetech) as an intravitreous injection for treatment of all subtypes of neovascular (wet) age-related macular degeneration (AMD). The...
July 18, 2005 (Issue 1213)  
  • Vitamin Supplements   
    Many patients ask their physicians whether they should take vitamins. Since the last Medical Letter article on this subject, more data have become available on the benefits and risks of taking...
  • Antibacterial Prophylaxis for Dental, GI and GU Procedures   
    Many physicians believe that antimicrobial prophylaxis before procedures that may cause transient bacteremia can prevent endocarditis and prosthetic joint infection in patients at increased risk for...
August 1, 2005 (Issue 1214)  
  • Atypical Antipsychotics in the Elderly   
    The FDA has reported that 5106 elderly patients with dementia treated with atypical (second generation) antipsychotics in 17 randomized controlled trials had a higher mortality rate (4.5% vs. 2.6%)...
  • Ropinirole for Restless Legs Syndrome   
    Ropinirole (Requip - GlaxoSmithKline), a dopamine agonist already available for treatment of Parkinson's disease, is now the first drug approved by the FDA for treatment of moderate to severe...
  • In Brief: Palladone Withdrawn   
    The Medical Letter review of Palladone (hydromorphone HCl) extended-release capsules (March 14, 2005) warned that a lethal dose could be released if the new formulation was taken with...
  • In Brief: Vitamin B12 Nasal Spray   
    A nasal spray formulation of cyanocobalamin (Nascobal – Questcor) has been approved by the FDA for maintenance treatment of vitamin B12 deficiency. Nascobal is already...
August 15, 2005 (Issue 1215)  
  • Sildenafil (Revatio) for Pulmonary Arterial Hypertension   
    The Medical Letter reported last year that sildenafil (Viagra - Pfizer) appeared to be effective for idiopathic pulmonary arterial hypertension (PAH), but confirmation from a...
  • Duloxetine (Cymbalta) for Diabetic Neuropathic Pain   
    Duloxetine hydrochloride (Cymbalta - Lilly), a selective serotonin and norepinephrine reuptake inhibitor (SNRI) available for treatment of depression, has also been approved by the FDA for...
  • Drugs for Head Lice   
    Superseded by The Medical Letter "Drugs for Head Lice" - Issue 1508, November 21, 2016Head lice occur in all age groups, but especially in elementary school children during the winter months....
  • Acetylcysteine (Acetadote) for Acetaminophen Overdosage   
    Acetaminophen (paracetamol; Tylenol, and others) taken in overdosage can cause severe hepatic injury and death. Acetaminophen poisoning is treated with (N-)acetylcysteine. Available for many...
  • AmpliChip CYP450 Test   
    The FDA recently cleared the AmpliChip CYP450 Test (Roche), which analyzes blood-derived DNA to detect genetic variations in the activity of cytochrome P450 (CYP) enzymes CYP2D6 and CYP2C19...
  • Vitamin C Addendum   
    The recent Medical Letter article on Vitamin Supplements (July 18, 2005) stated in its conclusion that there is no convincing evidence that taking supplements of vitamin C prevents any...
September 12, 2005 (Issue 1217)  
  • Tigecycline (Tygacil)   
    Tigecycline (Tygacil - Wyeth), a derivative of minocycline, is a new intravenous (IV) antibiotic approved for treatment of complicated intra-abdominal and skin and skin-structure infections.
  • Pregabalin (Lyrica) for Neuropathic Pain and Epilepsy   
    Pregabalin (Lyrica - Pfizer), a structural analog of gamma-aminobutyric acid (GABA) similar to gabapentin (Neurontin - Pfizer, and others), which recently became available generically,...
September 28, 2005 (Issue 1218)  
October 10, 2005 (Issue 1219)  
  • Second-Generation Antipsychotics - Aripiprazole Revisited   
    Aripiprazole (Abilify - Bristol-Myers Squibb/Otsuka), a second-generation (atypical) antipsychotic drug, was approved by the FDA in 2002 for treatment of schizophrenia and more recently for...
  • InstaRead Lithium System   
    The InstaRead Lithium System (ReliaLAB), an office test that only requires a finger stick to measure lithium serum concentrations, has been cleared by the FDA and is now available. Standard...
  • Tipranavir (Aptivus) for HIV   
    Tipranavir (Aptivus - Boehringer Ingelheim), a new protease inhibitor, has received accelerated approval from the FDA. It must be given with ritonavir (Norvir). The combination is...
October 24, 2005 (Issue 1220)  
November 7, 2005 (Issue 1221)  
November 21, 2005 (Issue 1222)  
December 5, 2005 (Issue 1223)